[Neurotransplantation, critical analysis and perspectives]

Basic morphological and functional properties of basal ganglia are described and their role in the development of Parkinson's disease is discussed in detail. Based on recent experimental data, the problem of human autologous adrenal medulla transplants as well as human dopaminergic neurons is analyzed and prospective approaches to successful therapeutic interventions are considered mainly from the molecular and immunobiological point of view. The relative limitations of the regenerative capacity and transplantability of the nervous tissue are assessed and compared with the critical developmental periods of human neurogenesis (Fig. 6, Ref. 47.).