Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New Treatment of Wound Healing With Allogenic Acellular Human Skin Graft: Preclinical Assessment and In Vitro Study.

Transplantation proceedings·2020
Same author

Transplantation of a New Biological Product in Rare Diseases, Such as Epidermolysis Bullosa: Response and Clinical Outcome.

Transplantation proceedings·2020
Same author

Use of a filtration plate in the MTT assay.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Mechanical properties of bone fixation devices prepared from a human allogenic bone.

Transplantation proceedings·2007
Same author

The clinical basis for making treatment decisions in children with cerebral palsy.

Ortopedia, traumatologia, rehabilitacja·2007

Related Experiment Video

Updated: Jul 25, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

Preserved tissue allografts in reconstructive surgery.

J Komender1, W Marczynski, D Tylman

  • 1Department of Transplantology & Central Tissue Bank, Medical University in Warsaw, ul.Chalubinskiego 5, 02-004 Warszawa, Poland; Author for correspondence (Fax: 226295282;

Cell and Tissue Banking
|July 17, 2004
PubMed
Summary

This study evaluates radiation-sterilized allografts, including lyophilized bone, frozen bone, and cartilage, for surgical reconstruction. Graft rebuilding shows prognostic value, and preserved bone and cartilage offer effective reconstructive options.

More Related Videos

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
09:30

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation

Published on: July 18, 2025

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
09:14

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Related Experiment Videos

Last Updated: Jul 25, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
09:30

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation

Published on: July 18, 2025

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
09:14

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Area of Science:

  • Orthopedic Surgery
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Allografts are crucial in reconstructive surgery.
  • Various preservation methods (lyophilization, freezing, saline) and sterilization techniques (radiation) impact allograft efficacy.
  • Estimating allograft viability and determining optimal surgical indications are ongoing challenges.

Purpose of the Study:

  • To present treatment outcomes using three types of radiation-sterilized allografts: lyophilized bone, deep-frozen bone, and preserved cartilage.
  • To aid in evaluating tissue bank allografts and establishing surgical indications and contraindications.
  • To analyze prognostic factors, such as graft rebuilding, in bone allograft transplantation.

Main Methods:

  • Comparison of 'indices of coincidence' in 1014 patients post-lyophilized bone transplantation.
  • Analysis of treatment results in 1125 patients receiving frozen, radiation-sterilized allogenic bone grafts.
  • Evaluation of 437 patients undergoing facial reconstruction with radiation-sterilized human costal cartilage preserved in saline, with follow-up ranging from 24-190 months.

Main Results:

  • Graft rebuilding appears to be a significant prognostic indicator in bone allograft treatment.
  • Frozen, radiation-sterilized allogenic bone grafts reduced surgery extent and duration, with near-complete substitution in 3-8 months.
  • In cartilage transplantations, 33.5% achieved very good results and 41.8% satisfactory results; 19.9% had unsatisfactory outcomes. Causes included post-traumatic changes (42.2%), congenital malformations (29.0%), and inflammation (16.7%).

Conclusions:

  • Radiation-sterilized allografts, including lyophilized bone, frozen bone, and preserved cartilage, demonstrate utility in various surgical reconstructions.
  • The 'rebuilding of graft' metric holds potential prognostic value for bone allografts.
  • Preserved allografts can effectively reduce surgical burden and achieve significant tissue substitution, with cartilage yielding good to satisfactory results in facial reconstruction.