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Related Experiment Video

Updated: Jul 17, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Bone allograft in revision total knee replacement.

M Salai¹, I Dudkiewicz, A Blankstein

¹Department of Orthopedic Surgery 'A', The Chaim Sheba Medical Center, Tel Hashomer, Israel; Author for correspondence (Tel.: 972-3-5302 2623; Fax: 972-3-530 2523;

Cell and Tissue Banking

|July 17, 2004

Summary

Revision total knee replacement (TKR) often requires bone reconstruction. Bone allografts demonstrate good functional outcomes for TKR bone loss, necessitating careful planning and bone banking.

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Area of Science:

Orthopedic surgery
Biomaterials science
Regenerative medicine

Background:

Revision total knee replacement (TKR) frequently involves significant bone loss.
Addressing bone defects is crucial for stable prosthesis revision.
Bone allografts are a common reconstructive option.

Purpose of the Study:

To evaluate the efficacy of bone allografts in revision total knee replacement.
To classify bone loss patterns in revision TKR and assess outcomes.
To identify factors critical for successful allograft use in TKR revision.

Main Methods:

Retrospective review of 137 revision TKR cases (1990-1996).
Analysis of 91 patients who received bone allografts for bone reconstruction.
Classification of bone defects into Types I, II, and III (minor, moderate, large) and locations (A, B).

Main Results:

Bone allografts were utilized in 67% of revision TKR cases.
Good functional outcomes were observed when using bone allografts.
Treatment results correlated with the type and extent of bone loss.

Conclusions:

Bone allografts are effective for reconstructing bone loss in revision TKR.
Preoperative planning and accurate bone defect classification are essential.
A well-stocked bone bank is critical for successful revision TKR with allografts.