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Beta2-microglobulin adsorption column reduces digoxin trough level during hemodialysis: three case reports

Shuichi Tsuruoka1, Michi Wakaumi, Hisashi Yamamoto

  • 1Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan. tsuru@jichi.ac.jp

Therapeutic Drug Monitoring
|July 17, 2004
PubMed

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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

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Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

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In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
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Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...