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CAM and NK Cells
1Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Abstract:
It is believed that tumor development, outgrowth and metastasis are under the surveillance of the immune system. Although both innate and acquired immune systems play roles, innate immunity is the spearhead against tumors. Recent studies have revealed the critical role of natural killer (NK) cells in immune surveillance and that NK cell activity is considerably influenced by various agents, such as environmental factors, stress, foods and drugs. Some of these NK cell stimulants have been used in complementary and alternative medicine (CAM) since ancient times. Therefore, the value of CAM should be re-evaluated from this point of view. In this review, we overview the intimate correlation between NK cell functions and CAM agents, and discuss possible underlying mechanisms mediating this. In particular, neuro-immune crosstalk and receptors for CAM agents are the most important and interesting candidates for such mechanisms.
Insights
Natural killer (NK) cells are crucial for immune surveillance against tumors. This review explores how complementary and alternative medicine (CAM) agents may influence NK cell activity, suggesting a re-evaluation of CAM
Area of Science:
- Immunology
- Oncology
- Integrative Medicine
Background:
- Tumor development, growth, and metastasis are monitored by the immune system, with innate immunity acting as a primary defense.
- Natural killer (NK) cells play a vital role in this immune surveillance.
- NK cell activity is influenced by diverse factors including environmental elements, stress, diet, and medications.
Purpose of the Study:
- To review the relationship between NK cell functions and complementary and alternative medicine (CAM) agents.
- To discuss potential mechanisms underlying the influence of CAM on NK cells.
Main Methods:
- Literature review focusing on studies examining NK cell activity and CAM.
- Analysis of potential neuro-immune pathways and receptor interactions involved in CAM effects on NK cells.
Main Results:
- NK cell activity is demonstrably affected by various agents, some of which are utilized in CAM.
- Neuro-immune crosstalk and specific receptor interactions are proposed as key mechanisms mediating CAM's impact on NK cells.
Conclusions:
- CAM agents may modulate NK cell function, highlighting the need to re-evaluate their role in cancer surveillance.
- Understanding these interactions could offer novel therapeutic strategies in oncology and integrative medicine.
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