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Related Experiment Videos

Thyroid dysfunction and cardiological management in patients receiving amiodarone.

Anna Gabriela Fuks1, Mário Vaisman, Alexandru Buescu

  • 1Hospital Universitário Clementino Fraga Filho, UFRJ, Rio de Janeiro, Brazil. agfuks@yahoo.com.br

Arquivos Brasileiros De Cardiologia
|July 17, 2004
PubMed
Summary

A high prevalence of thyroid dysfunction (33.9%) was observed in patients taking amiodarone, particularly those with anti-thyroid peroxidase (anti-TPO) antibodies. This highlights the need for routine thyroid monitoring in these patients.

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Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Amiodarone is an effective antiarrhythmic drug.
  • Amiodarone is known to cause thyroid dysfunction.
  • Monitoring thyroid function in patients on amiodarone is crucial.

Purpose of the Study:

  • To determine the prevalence of thyroid dysfunction in patients receiving amiodarone.
  • To identify factors associated with amiodarone-induced thyroid dysfunction.
  • To assess cardiologists' perspectives on managing amiodarone's effects on thyroid function.

Main Methods:

  • Serum levels of TSH, free T4, and total T3 were measured in 56 patients on chronic amiodarone therapy.
  • Anti-TPO antibodies were assessed.
  • Thyroid dysfunction (TD) was defined by changes in TSH levels.

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Main Results:

  • The prevalence of thyroid dysfunction was 33.9%.
  • Anti-TPO positivity was significantly higher in patients with TD (P=0.02) and in those with anti-TPO antibodies (80% vs 29.4%; P=0.04).
  • Hypothyroidism (subclinical and clinical) and hyperthyroidism (subclinical and clinical) were observed. Cardiologists showed varied approaches to routine thyroid monitoring.

Conclusions:

  • A high prevalence of thyroid dysfunction necessitates implementing routine laboratory monitoring for patients on amiodarone.
  • There is significant disagreement among cardiologists regarding the appropriate follow-up for amiodarone-treated patients' thyroid function.