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Updated: Aug 23, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Regional and systemic hemorheological disorders during feet diabetic gangrene
Nugzar Pargalava1, Maya Mantskava, George McHedlishvili
1N. Bokhua Center of Angiology and Vascular Surgery, 1 Chachava St., 0159 Tbilisi, Georgia.
Abstract:
We investigated the RBC aggregability in the patients with the foot diabetic gangrenes: in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the "Georgian technique" that is sensitive and provided us with direct and quantitative data. We found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation. Therefore, the sources of the systemic hemorheological disorders were the primarily damaged tissues. Taking into account that the blood is uninterruptedly flowing and mixing together in the whole circulatory bed we conclude that in the systemic circulation a certain compensatory mechanism provide for a partial normalization of the blood rheological properties, since the RBC aggregability never reaches the level in the blood of the healthy people.
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