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Related Experiment Videos

Id-1 expression and cell survival.

Y-C Wong1, X Wang, M-T Ling

  • 1Department of Anatomy, Cancer Biology Lab, Faculty of Medicine, and Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China. ycwong@hkuc.hku.hk

Apoptosis : an International Journal on Programmed Cell Death
|July 20, 2004
PubMed
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The Id-1 protein promotes cancer cell growth and survival by regulating cell proliferation and preventing apoptosis. Targeting Id-1 offers a potential therapeutic strategy for treating human cancers.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cellular Regulation

Background:

  • Id (inhibitor of differentiation or DNA binding) helix-loop-helix (HLH) proteins are regulators of cell differentiation.
  • Emerging evidence implicates Id proteins, particularly Id-1, in promoting cell proliferation and survival.
  • Id-1 upregulation is observed in various human cancers and correlates with advanced tumor stage.

Purpose of the Study:

  • To review current evidence on Id-1's role in cell proliferation and survival.
  • To discuss Id-1's significance in malignant transformation.
  • To highlight molecular mechanisms and therapeutic implications of Id-1 inactivation in cancer.

Main Methods:

  • Literature review of recent studies on Id-1 function in mammalian cells and cancer.

Related Experiment Videos

  • Analysis of Id-1's impact on cell cycle progression, tumor suppressor pathways, and apoptosis.
  • Examination of Id-1's association with tumor stage and its role in tumorigenesis.

    • Main Results:

    • Id-1 promotes cell proliferation and cell cycle progression by inactivating tumor suppressors and activating growth pathways.
    • Ectopic Id-1 expression enhances cancer cell proliferation under stress and confers resistance to apoptosis.
    • Id-1 expression levels are linked to advanced tumor stage in human cancers.

    Conclusions:

    • Id-1 acts as a positive regulator of cell growth and is crucial for tumor cell proliferation.
    • Understanding Id-1's molecular mechanisms is key to developing targeted cancer therapies.
    • Inactivation of Id-1 presents a promising therapeutic avenue for human cancer treatment.