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Related Experiment Videos

[Becaplermin gel (Regranex gel)].

P Senet1

  • 1Service de Gérontologie V, Hôpital Charles Foix, 7, avenue de la République, 94205 Ivry-sur-Seine.

Annales De Dermatologie Et De Venereologie
|July 20, 2004
PubMed
Summary

Becaplermine gel (Regranex) accelerates diabetic wound healing by promoting cell growth and tissue formation. This topical treatment is safe and effective for neuropathic diabetic ulcers when used with standard wound care.

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Area of Science:

  • Dermatology
  • Wound Healing
  • Regenerative Medicine

Background:

  • Becaplermine gel (Regranex) is a topical hydrogel containing recombinant human Platelet-Derived Growth Factor-BB (rhPDGF-BB).
  • It is indicated as an adjuvant therapy for neuropathic diabetic ulcers under 5 cm² in the absence of ischemia, alongside standardized wound care.

Purpose of the Study:

  • To evaluate the efficacy and safety of becaplermine gel in promoting cutaneous wound healing.
  • To assess the impact of rhPDGF-BB on fibroblast proliferation, migration, and extracellular matrix deposition.

Main Methods:

  • Topical application of 0.01% becaplermine gel in multidose tubes.
  • Clinical trials in humans with lower extremity diabetic neuropathic ulcers and decubitus sores.
  • Local toxicity and pharmacokinetic studies.

Main Results:

  • Accelerated healing demonstrated in human clinical trials, with increased granulation tissue formation and epithelialization.
  • Animal models showed enhanced wound healing, granulation tissue synthesis, and extracellular matrix deposition.
  • Local toxicity studies were negative; systemic absorption was minimal, with excellent local and systemic tolerance.

Conclusions:

  • Becaplermine gel (Regranex) is a safe and effective topical treatment that speeds cutaneous wound healing.
  • It is the only commercially available topical growth factor for wound healing, promoting granulation and epithelialization.
  • The gel is easy to use with a single daily application and shows minimal adverse effects.

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