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Anticardiolipin antibodies as a risk factor of atherosclerosis in intermittent claudication

José Maria Pereira de Godoy1, Fernando Batigália, Maria Regina Pereira de Godoy

  • 1Department of Cardiology and Vascular Surgery of São José do Rio Preto University School of Medicine, São Paulo, Brazil. godoyjmp@riopreto.com.br

Angiology
|July 20, 2004
PubMed

Insights

Elevated anticardiolipin antibodies significantly increase the risk of developing intermittent claudication. This study found a 3.8 times higher risk in patients with high antibody levels, highlighting a key association.

Area of Science:

  • Vascular Medicine
  • Immunology
  • Cardiology

Background:

  • Anticardiolipin antibodies are recognized risk factors for atherosclerosis.
  • Intermittent claudication is a common manifestation of peripheral artery disease.

Purpose of the Study:

  • To investigate the association between anticardiolipin antibodies and intermittent claudication.
  • To quantify the risk of intermittent claudication in individuals with elevated anticardiolipin antibody levels.

Main Methods:

  • A case-control study comparing 40 patients with intermittent claudication to 40 healthy controls.
  • Quantitative measurement of immunoglobulin G (IgG) and IgM anticardiolipin antibodies using enzyme-linked immunosorbent assay (ELISA).
  • Statistical analysis using the relative risk test with a 95% confidence interval.

Main Results:

  • Elevated anticardiolipin antibody levels were found in 23 patients and 6 controls.
  • Patients with elevated anticardiolipin antibodies had a 3.833-fold increased risk (95% CI: 1.749-8.4) of intermittent claudication (p < 0.0001).

Conclusions:

  • Elevated anticardiolipin antibody levels are significantly associated with an increased risk of intermittent claudication.
  • Anticardiolipin antibodies may play a role in the pathogenesis of peripheral artery disease leading to intermittent claudication.

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