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Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
Published on: January 4, 2018
Two birds with one metallic stone: single-pot catalysis of fundamentally different transformations
Alain Ajamian1, James L Gleason
1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada.
Abstract:
Advances in metal catalysis have revolutionized organic synthesis, with the scope of metal-catalyzed reactions now covering nearly all areas of carbon-carbon, carbon-hydrogen, and carbon-heteroatom bond formation. For years, the goal was to develop catalysts that were highly selective for a single transformation. However, a promising current area of research is the use of a single catalyst to mediate more than one transformation in a selective manner. Whereas much early work was focused on using a catalyst for several similar transformations, recent investigations have shown that it is also possible to employ a single catalyst for several very different transformations in a single reaction sequence. This Minireview focuses on methods in which the mechanisms of the transformations are fundamentally very different.
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