Related Experiment Videos
Alverine citrate induced acute hepatitis
Mehmet Arhan1, Seyfettin Koklu, Aydln-S Koksal
1Kavaklik mah, Ahmet Apaydln cad, Sultan Apartment, No 39/7, Sahinbey 27060, Gaziantep, Turkey.
World Journal of Gastroenterology
|July 20, 2004
Summary
Alverine citrate, a smooth muscle relaxant, may cause liver injury. This case suggests a metabolic, rather than immune, cause for drug-induced liver toxicity from alverine citrate.
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Alverine citrate is a widely prescribed smooth muscle relaxant.
- Hepatotoxicity associated with alverine citrate is rarely reported.
- Previous literature documented one case implicating alverine citrate-induced liver injury.
Observation:
- A 34-year-old woman presented with elevated liver function tests.
- Hepatitis from other causes was excluded.
- Elevated liver enzymes were attributed to alverine citrate treatment.
Findings:
- The patient exhibited no hypersensitivity manifestations.
- Previous studies noted a lack of dose-dependent toxicity for alverine citrate.
- These factors suggest a metabolic idiosyncratic toxicity mechanism.
Implications:
- This case highlights a potential metabolic pathway for alverine citrate hepatotoxicity.
- Further research is needed to elucidate the exact mechanism of alverine citrate-induced liver injury.
- Clinicians should consider alverine citrate when evaluating drug-induced liver toxicity.