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[Giant clivus chordomas. Are extensive surgeries really justified?]
Gerardo Guinto1, Fabrizio Cohn, Norma Aréchiga
1Servicio de Neurocirugía, Hospital de Especialidades del Centro Médico, Nacional Siglo XXI, Ciudad de México. gguinto@prodigy.net.mx
Gaceta Medica De Mexico
|July 21, 2004
Summary
Giant clivus chordomas pose surgical challenges. Complete tumor resection significantly improves patient outcomes and disease-free survival, even for large tumors.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Context:
- Clivus chordomas, particularly giant ones, present significant surgical challenges due to their location and biological behavior.
- Current cranial base surgery techniques are being evaluated for their efficacy in managing these complex tumors.
Purpose:
- To assess the impact of surgical resection extent on functional outcomes and disease-free survival in patients with giant clivus chordomas.
- To investigate potential correlations between histopathological findings and the clinical course of these tumors.
Summary:
- Eleven patients with giant clivus chordomas underwent surgery adhering to cranial base surgery criteria.
- Total resection was achieved in 8 patients, partial in 3, with all experiencing functional improvement, especially those with complete resection.
- Disease-free survival was notably longer in patients with more extensive resections.
Impact:
- Complete resection of giant clivus chordomas leads to improved postoperative functional outcomes.
- Ample surgical resection correlates with extended disease-free survival in patients with these challenging tumors.
- Histological subtype (typical or chondroid) did not show a correlation with clinical prognosis.