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Updated: Aug 23, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
Published on: October 10, 2017
[Phosphorylation of tau and Alzheimer's disease]
1Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología Ignacio Chávez.
Abstract:
Tau is an important component of neuronal cytosqueleton; the protein stabilizas microtubules, maintains cell shape and axonal transport mechanisms. However, for unknown reasons tau experiments important postranslation modifications including enhanced phosphorilation due to unbalanced activity between kinases and phosphatases, affecting its normal biological function. Under these circumstances tau begins to aggregate into neurofibrillary tangles (NFTS) complexes which are pathological hallmarks of Alzheimer's disease together with senile plaques. This review is mainly concerned with the role that different kinase play into the regulation of tau structure and function.
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