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First practical colorimetric assay of lithium in serum
E Chapoteau1, B P Czech, W Zazulak
1Miles Incorporated, Tarrytown, NY 10591.
Clinical Chemistry
|September 1, 1992
Abstract:
We report a colorimetric method for determining lithium in blood serum without sample pretreatment or solvent-extraction steps. The method is based on a novel chromogenic ionophore that exhibits exceptionally high selectivity (much greater than 4000:1) for lithium over sodium. The standard curve for the method is linear up to 3.5 mmol/L and exceeds the therapeutic range for lithium. The results for 57 patients' samples correlated well with results obtained with an Instrumentation Laboratory flame photometer (r = 0.97).