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Related Experiment Videos

The genes for schizophrenia: finally a breakthrough?

Brian H Shirts1, Vishwajit Nimgaonkar

  • 1Western Psychiatric Institute and Clinic, Room 443, 3811 O"Hara Street, Pittsburgh, PA 15213, USA.

Current Psychiatry Reports
|July 21, 2004
PubMed
Summary

Recent advances identify schizophrenia susceptibility genes, with Neuregulin 1 (NRG1) and Dysbindin (DTNBP1) showing the strongest evidence. Further research is needed to confirm these genetic links.

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Area of Science:

  • Genetics
  • Psychiatry
  • Neuroscience

Background:

  • Schizophrenia genetics research has identified several susceptibility genes.
  • Recent studies show increased consistency in replication, generating excitement in the field.

Purpose of the Study:

  • To review gene mapping methods for schizophrenia.
  • To evaluate genetic association studies for six key susceptibility genes: catechol-O-methyl transferase (COMT), neuregulin 1 (NRG1), dysbindin (DTNBP1), regulator of G-protein signaling 4 (RGS4), G72, and D-amino-acid oxidase (DAAO).

Main Methods:

  • Review of gene mapping methodologies.
  • Evaluation of peer-reviewed genetic association studies.
  • Analysis of evidence supporting specific schizophrenia-associated genes.

Main Results:

  • Gene mapping methods have varying strengths and challenges.
  • Evidence supporting the implicated genes is inconsistent.
  • Neuregulin 1 (NRG1) and Dysbindin (DTNBP1) have the strongest supporting evidence among the evaluated genes.

Conclusions:

  • While credible evidence exists for all six genes, further investigation is warranted.
  • Future research should include comprehensive polymorphism analyses, meta-analyses, and functional studies of risk alleles.

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