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Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
Tomomi Noguchi1, Hiroko Sano, Rumiko Shimazawa
1Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Bioorganic & Medicinal Chemistry Letters
|July 21, 2004
Abstract:
Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.