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Updated: Aug 18, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator
Noah Tu1, J T Link, Bryan K Sorensen
1Metabolic Disease Research, Abbott Laboratories, Dept 4CB, Building AP-10, Rm. L-14, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA.
Abstract:
Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.
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