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Aminotriazine 5-HT7 antagonists
Ronald J Mattson1, Derek J Denhart, John D Catt
1Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. mattsonr@bms.com
Bioorganic & Medicinal Chemistry Letters
|July 21, 2004
Abstract:
The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist.