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Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue

Rumiko Shimazawa1, Mika Gochomori, Ryuichi Shirai

  • 1Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Bioorganic & Medicinal Chemistry Letters
|July 21, 2004
PubMed

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
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