Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medication-overuse headache: a worldwide problem.

Hans-Christoph Diener1, Volker Limmroth

  • 1Department of Neurology, University Hospital Essen, Germany. h.diener@uni-essen.de

The Lancet. Neurology
|July 21, 2004
PubMed
Summary

Medication overuse headache (MOH) affects about 1% of the population globally. Successful prevention requires restricting monthly medication doses, as withdrawal therapy is the primary treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventive migraine treatment with eptinezumab reduced acute headache medication and headache frequency to below diagnostic thresholds in patients with chronic migraine and medication-overuse headache.

Headache·2021
Same author

Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial.

Circulation·2021
Same author

Doubtful use of placebo following placebo in recent controlled trials of lasmiditan and ubrogepant for the treatment of migraine attacks.

Cephalalgia : an international journal of headache·2021
Same author

Changes in anticoagulant prescription patterns over time for patients with atrial fibrillation around the world.

Journal of arrhythmia·2021
Same author

MMW Fortschritte der Medizin·2021
Same author

COVID-19 Vaccine-Associated Cerebral Venous Thrombosis in Germany.

Annals of neurology·2021

Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Medication overuse headache (MOH) is a significant global health concern.
  • Epidemiological studies indicate that up to 4% of the population may overuse analgesics for pain conditions like migraine.
  • Approximately 1% of the general population in Europe, North America, and Asia suffer from MOH.

Purpose of the Study:

  • To provide insights into the clinical and pharmacological features of MOH.
  • To highlight the variability in critical monthly doses and frequencies based on primary headache disorders and drug types.
  • To acknowledge the updated international classification of headache disorders for improved MOH diagnosis.

Main Methods:

  • Review of recent clinical studies on medication overuse and headache.
  • Analysis of epidemiological data on analgesic overuse and MOH prevalence.
  • Examination of diagnostic criteria from the International Classification of Headache Disorders.

Main Results:

  • Critical monthly doses and frequencies for medication overuse vary significantly.
  • These variations are dependent on the primary headache disorder and the specific drug being overused.
  • New diagnostic criteria and headache entities facilitate MOH identification.

Conclusions:

  • Withdrawal therapy is the sole effective treatment for MOH.
  • Strict restriction of monthly medication doses is essential for successful MOH prevention.
  • Understanding drug-specific and condition-specific overuse patterns is key to managing MOH.

Related Experiment Videos