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Related Experiment Videos

Indapamide-associated Stevens-Johnson syndrome.

S A Spinler1, N J Globus, J Z Raymond

  • 1Philadelphia College of Pharmacy and Science, Pennsylvania 19104.

Cutis
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Stevens-Johnson syndrome, a severe skin reaction, can occur after taking indapamide for hypertension. Early recognition and drug withdrawal are key to recovery.

Area of Science:

  • Dermatology
  • Pharmacology
  • Ophthalmology

Background:

  • Stevens-Johnson syndrome (SJS) is a severe mucocutaneous reaction often linked to drug exposure.
  • Hypertension is a common condition treated with various medications, including diuretics like indapamide.

Observation:

  • A 45-year-old woman developed symptoms of SJS within two days of initiating indapamide for hypertension.
  • Initial symptoms included headache, sore throat, cough, and conjunctival injection.
  • Skin eruptions appeared approximately two weeks later, affecting the conjunctiva, lips, face, neck, trunk, and extremities.

Findings:

  • The patient's symptoms resolved approximately eight days after discontinuing indapamide and commencing treatment.
  • Treatment involved cool compresses, antiseptics, ophthalmic antibiotics and steroids, and oral prednisone.

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Implications:

  • This case highlights the potential association between indapamide and Stevens-Johnson syndrome.
  • Clinicians should consider SJS in patients presenting with malaise, fever, and skin eruptions after indapamide ingestion.
  • Awareness of this rare but serious adverse drug reaction is crucial for timely diagnosis and management.