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¹Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University Frankfurt, Schleusenweg 2-16, D-60528 Frankfurt am Main, Germany. u.ziemann@em.uni-frankfurt.de

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Summary

This summary is machine-generated.

This review explores how transcranial magnetic stimulation (TMS) can assess drug effects on brain activity and how drugs influence TMS measures. It highlights TMS as a tool for studying drug actions and brain responses.

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Area of Science:

Neuroscience
Pharmacology
Neurophysiology

Background:

Transcranial magnetic stimulation (TMS) offers measures of cortical excitability.
Central nervous system (CNS) drugs impact neurotransmitter systems.
Understanding drug-CNS interactions is crucial in neuropharmacology.

Purpose of the Study:

To review the intricate relationship between TMS and drugs.
To explore TMS as a tool for characterizing drug effects on the brain.
To investigate drug-induced changes in cortical excitability.

Main Methods:

Utilizing single-dose CNS active drugs to test TMS pharmaco-physiological properties.
Employing TMS measures as biomarkers for acute drug effects.
Applying arrays of TMS measures to study drugs with complex or unknown mechanisms.

Main Results:

Single drug doses can validate TMS measures of cortical excitability.
TMS measures can serve as biological markers for acute drug effects.
TMS can reveal patterns of drug action, including acute vs. chronic differences and drug-induced neurochemical changes.

Conclusions:

TMS is a versatile tool for studying drug effects on cortical excitability.
TMS can elucidate drug mechanisms and differentiate acute from chronic effects.
Investigating TMS-induced changes in endogenous neurotransmitters is a key area of focus.