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Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia
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Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but

Christian A J Vosshenrich1, Ana Cumano, Werner Müller

  • 1Unité des Cytokines et Développement Lymphoïde, Institut National de la Santé et de la Recherche Médicale, Institut Pasteur, 75724 Paris, France.

Proceedings of the National Academy of Sciences of the United States of America
|July 21, 2004
PubMed

IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse. On the one hand, TSLP is able to give rise to a measurable B1 cell compartment derived from fetal liver pro-B cells, although, as is the case for B2 cells, it does not play a prevalent role in the development of this subset. On the other hand, TSLP drives the proliferation of pro-B cells from the fetal and neonatal liver, but in the bone marrow environment, B cell precursors require pre-B cell receptor expression for TSLP responsiveness.

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