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(1R,2R,3S,4S)-2-[(2R,3S)-2,3-Dimethyloxiran-2-yl]-3,4-bis(4-methoxybenzyloxy)cyclohexanol.

Y Kani1, S Ohba, S Amano

  • 1Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.

Acta Crystallographica. Section C, Crystal Structure Communications
|July 21, 2004
PubMed
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Researchers determined the relative configuration of a compound C(26)H(34)O(6) during the synthesis of immunosuppressant FR65814. An intramolecular hydrogen bond was identified between its hydroxy and epoxy groups.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry

Background:

  • The synthesis of complex organic molecules is crucial for drug discovery.
  • Immunosuppressant FR65814 is a target compound with potential therapeutic applications.

Purpose of the Study:

  • To determine the relative configuration of a key intermediate in the synthesis of immunosuppressant FR65814.
  • To characterize the structural features of the synthesized compound, C(26)H(34)O(6).

Main Methods:

  • Synthetic organic chemistry techniques were employed for the preparation of C(26)H(34)O(6).
  • Spectroscopic methods were used to elucidate the compound's structure and configuration.

Main Results:

  • The relative configuration of the title compound, C(26)H(34)O(6), was successfully determined.

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  • An intramolecular hydrogen bond was identified between the hydroxy and epoxy functional groups within the molecule.

    • Conclusions:

    • The established relative configuration provides critical information for the ongoing synthesis of immunosuppressant FR65814.
    • The presence of the intramolecular hydrogen bond may influence the compound's chemical properties and biological activity.