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Updated: Aug 23, 2026
Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
Published on: September 15, 2023
Molecular pathological analysis of mucinous adenocarcinomas of the stomach
Ming Wu1, Shuho Semba, Dong Li
1Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan.
Objective:
Mucinous adenocarcinomas (MACs) of the stomach usually show an invasive expansive growth and a poor prognosis. We examined the possibility of molecular pathological subtyping of MACs of the stomach.
Methods:
Forty-one formalin-fixed and paraffin-embedded MAC specimens of the stomach were analyzed. Mucin subtypes (MUC2, CD10, HGM, M-GGMC-1) and expression levels of hMLH1, p53 and Ki-67 were analyzed by immunohistochemistry as well as genetic alterations in the p53 gene and microsatellite instability (MSI).
Results:
According to both MSI and p53 status, these tumors were subclassified into three groups: the mutator-type tumors, the suppressor/p53-type tumors and the unclassified tumors. The mutator-type tumors demonstrated lower p53 expression and had lower proliferative activity than the suppressor/p53-type tumors, whereas most of the suppressor/p53-type tumors expressed CD10. However, there was no significant difference between the mutator- and suppressor/p53-type tumors in clinicopathological parameters including the patients' outcome.
Conclusion:
Our results indicate that MACs of the stomach are composed of at least three subtypes according to the molecular pathological background for their carcinogenesis. Further study of carcinomas with detailed morphological and biological phenotyping of each subtype may provide useful information for better clinical management.
