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[Neuropsychology and epilepsy].

J Campos-Castelló1, S Campos-Soler

  • 1Servicio de Neuropediatría, Hospital Clínico San Carlos, Madrid, Spain. jcampos.hcsc@salud.madrid.org

Revista De Neurologia
|July 21, 2004
PubMed
Summary

Children with epilepsy face higher risks of cognitive disorders due to epilepsy itself, pre-existing conditions, and antiepileptic drug (AED) side effects. While generally mild, AED cognitive impacts can be significant for individual children.

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[Idiopathic epilepsies: some therapeutic aspects].

Revista de neurologia·2004

Area of Science:

  • Pediatric Neurology
  • Neuropsychology
  • Pharmacology

Context:

  • Epileptic children exhibit a threefold increased risk of cognitive disorders compared to healthy peers.
  • Cognitive impairments in epilepsy are multifactorial, influenced by the condition, co-occurring deficits, and antiepileptic drug (AED) effects.

Purpose:

  • To analyze the relationship between neuropsychology and epilepsy in pediatric patients.
  • To understand the factors contributing to cognitive deterioration in children with epilepsy.

Summary:

  • Cognitive effects of AEDs vary by drug, dosage, and polypharmacy, presenting both adverse and potentially beneficial outcomes.
  • While generally mild, AED side effects on cognition and behavior are influenced by epilepsy syndrome, etiology, treatment response, and polypharmacy.
  • Newer AEDs, with better-understood mechanisms, can improve cognitive function by controlling seizures.

Impact:

  • Highlights the need for reliable assessment tools (e.g., MEDDRA) to evaluate AED side effects.
  • Emphasizes the importance of gradual drug introduction and monitoring for managing cognitive impacts.
  • Underscores the necessity of cognitive monitoring during epilepsy therapy to forecast and manage progression.

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