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Related Experiment Videos

High altitude cerebral edema.

Peter H Hackett1, Robert C Roach

  • 1International Society for Mountain Medicine and Colorado Center for Altitude Medicine and Physiology, Ridg-way, Colorado 81432, USA. hackett@hypoxia.net

High Altitude Medicine & Biology
|July 22, 2004
PubMed
Summary
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High altitude cerebral edema (HACE) is a rare but fatal condition from rapid ascent. Prompt recognition and treatment, including descent and steroids, are crucial for managing HACE.

Area of Science:

  • Altitude sickness research
  • Neurology
  • Travel medicine

Background:

  • High altitude cerebral edema (HACE) is a severe complication of high-altitude exposure.
  • It is often associated with acute mountain sickness and high altitude pulmonary edema.

Purpose of the Study:

  • To review the epidemiology, clinical presentation, pathophysiology, treatment, and prevention of HACE.
  • To elucidate the mechanisms behind HACE's vasogenic edema and blood-brain barrier disruption.

Main Methods:

  • Literature review of HACE.
  • Analysis of current theories on HACE pathophysiology.
  • Summary of treatment and prevention strategies.

Main Results:

  • HACE presents with altered consciousness, psychiatric changes, confusion, and ataxia.

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  • The leading theory suggests HACE involves vasogenic edema due to blood-brain barrier disruption.
  • Treatment and prevention mirror other altitude illnesses but emphasize descent and corticosteroids.

    • Conclusions:

    • HACE requires prompt recognition and management, with descent and steroids being key interventions.
    • Understanding HACE pathophysiology is vital for effective prevention and treatment strategies.
    • Case histories illustrate the critical clinical features of this disorder.