Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cortical language activation in aphasia: a functional MRI study.

Xiao-jun Xu1, Min-ming Zhang, De-sheng Shang

  • 1Department of Radiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Chinese Medical Journal
|July 22, 2004
PubMed
Summary

Functional magnetic resonance imaging (fMRI) reveals distinct language processing networks in healthy individuals versus aphasic patients. Aphasia patients showed altered brain activation patterns, suggesting functional reorganization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Explanation and interpretation of pediatric blood requirement recommendations in the national health standard "Guideline for pediatric transfusion"].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2026
Same author

Breastfeeding initiation and duration: links to physical, mental and behavioural health in US children aged 3-5 years.

BMJ nutrition, prevention & health·2026
Same author

Xenopax for the treatment of steroid-refractory acute graft-versus-host disease: the RELAX study.

Military Medical Research·2025
Same author

The role of miR-10b-5p in prostate cancer and its exosome-mediated angiogenesis effect.

Cancer genetics·2025
Same author

Prognostic Risk Model of Megakaryocyte-Erythroid Progenitor (MEP) Signature Based on AHSP and MYB in Acute Myeloid Leukemia.

Biomedicines·2025
Same author

[Explanation and interpretation of blood transfusion provisions for children undergoing cardiac surgery in the national health standard "Guideline for pediatric transfusion"].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2025

Area of Science:

  • Neuroimaging
  • Neurolinguistics
  • Cognitive Neuroscience

Background:

  • Functional neuroimaging is a key tool in neurolinguistic research for both healthy individuals and patients with brain damage.
  • Understanding the neural underpinnings of language processing is crucial for diagnosing and treating language disorders.

Purpose of the Study:

  • To investigate the neural basis of language processing in normal subjects.
  • To compare language processing networks between normal subjects and aphasic patients.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to map brain activity.
  • Six healthy subjects and three recovering aphasic patients performed a word generation task.
  • Regional neural activity was measured via signal change during multi-slice functional scanning.

Related Experiment Videos

Main Results:

  • Normal subjects exhibited a distributed language network across frontal, temporal, parietal, and occipital regions.
  • Aphasic patients showed no activation in the left inferior frontal gyrus, irrespective of lesion location.
  • Two aphasic patients displayed activation in right hemisphere regions not typically active in healthy subjects.

Conclusions:

  • fMRI combined with a word generation task is a viable method for assessing language function in aphasic patients.
  • The study identified potential remote effects of focal lesions and evidence of functional redistribution or reorganization in aphasic patients.