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Related Experiment Videos

Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rats.

D H Waalkens-Berendsen1, A Bär

  • 1TNO Nutrition and Food Research, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

Regulatory Toxicology and Pharmacology : RTP
|July 22, 2004
PubMed
Summary

Alpha-cyclodextrin (alpha-CD) was evaluated for embryotoxicity and teratogenicity in rats. No adverse effects were observed, indicating alpha-CD is safe for prenatal development at tested dietary levels.

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Area of Science:

  • Toxicology
  • Developmental Biology
  • Pharmacology

Background:

  • Alpha-cyclodextrin (alpha-CD) is a cyclic oligosaccharide with various applications.
  • Assessing the safety of alpha-CD during pregnancy is crucial for its potential use in pharmaceutical or food industries.

Purpose of the Study:

  • To investigate the potential embryotoxic and teratogenic effects of alpha-cyclodextrin (alpha-CD) in a rat model.
  • To determine the safety profile of alpha-CD during gestation.

Main Methods:

  • Pregnant Wistar rats were fed diets containing 0%, 1.5%, 5%, 10%, or 20% alpha-CD from day 0 to 21 of gestation.
  • Maternal reproductive parameters, fetal development (external, skeletal, visceral), and body weight were assessed.
  • A control group received 20% lactose.

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Main Results:

  • Alpha-cyclodextrin (alpha-CD) was well-tolerated by maternal rats, with no treatment-related deaths.
  • No significant differences in maternal weight gain, food consumption, or water intake were observed, except for slightly increased food intake in the highest alpha-CD group.
  • No external, visceral, or skeletal abnormalities were detected in fetuses, indicating no fetotoxic, embryotoxic, or teratogenic effects.

Conclusions:

  • Alpha-cyclodextrin (alpha-CD) does not exhibit embryotoxic or teratogenic effects in rats up to a dietary intake of 20%.
  • The study supports the safety of alpha-CD during prenatal development in the tested species and dosage range.