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Related Experiment Videos

Scanning electron microscope imaging of onychomycosis.

William P Scherer1, Michael David Scherer

  • 1College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.

Journal of the American Podiatric Medical Association
|July 22, 2004
PubMed
Summary

Scanning electron microscopy reveals the deep penetration of Trichophyton rubrum in geriatric toenails, explaining treatment challenges. This offers new insights into chronic fungal nail infections.

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Area of Science:

  • Medical Mycology
  • Dermatology
  • Microscopy

Background:

  • Onychomycosis, a toenail fungal infection, is common in the elderly.
  • Trichophyton rubrum is a frequent cause of onychomycosis.
  • High-resolution imaging of geriatric onychomycosis is lacking.

Observation:

  • Three-dimensional scanning electron microscopy images were generated from two geriatric patients with T. rubrum toenail infections.
  • Images captured the intricate structure and penetration of fungal hyphae within the toenail.

Findings:

  • The study visualized the pervasive integration and penetration of T. rubrum hyphal elements in chronic onychomycosis.
  • Microscopic evidence highlights the difficulty in eradicating fungal infections from the subungual space.

Implications:

  • Scanning electron microscopy provides valuable insights into the spatial orientation and behavior of fungal pathogens in nail infections.
  • Understanding fungal invasion patterns can inform future research on treatment strategies for difficult-to-treat onychomycosis.

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