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Related Concept Videos

Pharmacokinetics: Overview01:10

Pharmacokinetics: Overview

Pharmacokinetics is a scientific discipline that focuses on the journey of a drug within the body, encompassing four key stages: absorption, distribution, metabolism, and elimination. The first stage, absorption, involves the drug's transfer into the bloodstream. Several factors dictate the extent and speed of this process. For example, the liver often metabolizes oral drugs before they reach systemic circulation, leading to only partial absorption. In contrast, intravenous (IV) administration...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Published on: October 25, 2013

Vancomycin: an overview for the podiatric physician.

Robert G Smith1

  • 1Shoe String Podiatry, 22 Park Terr, Ormond Beach, FL 32174, USA.

Journal of the American Podiatric Medical Association
|July 22, 2004
PubMed
Summary

Vancomycin use is rising, increasing resistance. This review details vancomycin pharmacology and introduces a dosing nomogram to aid podiatric physicians in effective vancomycin treatment and improved patient outcomes.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Podiatric Medicine

Background:

  • Increasing vancomycin reliance for bacterial infections.
  • Emergence of vancomycin-resistant organisms necessitates cautious prescribing.
  • Podiatric physicians require guidance on vancomycin use.

Purpose of the Study:

  • To review vancomycin pharmacology, pharmacokinetics, and dosing.
  • To present evidence for vancomycin nomogram development and application.
  • To introduce a vancomycin dosing nomogram for podiatric physicians.

Main Methods:

  • Literature review of vancomycin pharmacology and pharmacokinetics.
  • Analysis of clinically based evidence for vancomycin nomograms.
  • Introduction of a practical vancomycin dosing nomogram.

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Last Updated: Jul 19, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

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Main Results:

  • Vancomycin dosing nomograms are evidence-based tools.
  • Nomograms can guide appropriate vancomycin selection and use.
  • Effective vancomycin management is crucial for combating resistance.

Conclusions:

  • Vancomycin dosing nomograms improve treatment efficacy.
  • These tools aid podiatric physicians in managing infections.
  • Optimized vancomycin use can lead to better patient outcomes and cost savings.