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Related Experiment Videos

Clinicopathologic analysis of 15 explanted hydroxyapatite implants.

David R Jordan1, Seymour Brownstein, Hamid Faraji

  • 1Department of Ophthalmology, University of Ottawa Eye Institute, 340 McLeon Street, Suite 104, Ottawa, Ontario K2P 1A4, Canada.

Ophthalmic Plastic and Reconstructive Surgery
|July 22, 2004
PubMed
Summary

Orbital implant infections often present with prolonged symptoms like discharge and inflammation, frequently necessitating implant removal. Early diagnosis is key, as recurrent discharge can delay identification of porous orbital implant infection.

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Area of Science:

  • Ophthalmology
  • Medical device infections
  • Histopathology

Background:

  • Orbital implants are used for prosthetic eye restoration.
  • Infection is a potential complication of orbital implants.
  • Suspected implant infection requires careful clinical and histopathological evaluation.

Purpose of the Study:

  • To detail clinical findings, treatments, and outcomes for patients with suspected orbital implant infections.
  • To analyze histopathologic findings in explanted orbital implants.
  • To guide diagnosis and management of orbital implant infections.

Main Methods:

  • Retrospective case series of 14 patients with 15 hydroxyapatite orbital implants.
  • Analysis of clinical data including symptoms, signs, and treatments.

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  • Histopathologic examination of explanted implants to identify inflammatory patterns and microorganisms.

    • Main Results:

    • Most common symptoms were discharge and socket tenderness; signs included conjunctival inflammation and pyogenic granuloma.
    • Clinical infection was documented in 13 of 14 patients.
    • Histopathology revealed acute and chronic inflammation, necrosis, and osseous metaplasia in most implants; microorganisms were identified in some cases.

    Conclusions:

    • Porous orbital implant infections can have a prolonged course, with recurrent discharge potentially delaying diagnosis.
    • Persistent inflammation, discharge, and pyogenic granuloma suggest implant infection requiring removal.
    • Orbital pain without inflammation may indicate other etiologies.