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Emerging technologies in transdermal therapeutics.

Victor M Meidan¹, Bozena B Michniak

¹Laboratory for Drug Delivery, Department of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, 111 Lock Street, Newark, NJ 07103, USA. vmeidan@hotmail.com

American Journal of Therapeutics

|July 22, 2004

Summary

New bioengineering techniques like iontophoresis and electroporation are revolutionizing transdermal drug delivery. These active enhancement technologies significantly expand the range of deliverable drugs, including large molecules.

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Area of Science:

Bioengineering
Dermatology
Pharmaceutics

Background:

Transdermal drug delivery was historically limited to drugs with specific physicochemical properties.
The stratum corneum presents a significant barrier to drug permeation.
Advances in bioengineering are overcoming these limitations.

Purpose of the Study:

To review emerging active enhancement technologies for transdermal drug delivery.
To discuss the impact of these technologies on future transdermal therapeutics.
To highlight the potential for delivering a wider range of molecules, including macromolecules.

Main Methods:

Review of iontophoresis, sonophoresis, electroporation, and microneedle arrays.
Analysis of how these technologies circumvent the stratum corneum barrier.

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Discussion of the implications for transdermal flux enhancement.

Main Results:

Active enhancement technologies transiently overcome the skin's barrier function.
These methods enable the transdermal delivery of macromolecules.
Significant increases in transdermal flux are achievable.

Conclusions:

Emerging bioengineering techniques dramatically expand transdermal drug delivery capabilities.
Macromolecule delivery via transdermal routes is becoming feasible.
These advancements promise to transform transdermal therapy.