Emerging technologies in transdermal therapeutics
Victor M Meidan1, Bozena B Michniak
1Laboratory for Drug Delivery, Department of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, 111 Lock Street, Newark, NJ 07103, USA. vmeidan@hotmail.com
Abstract:
Until very recently, the only drugs that could permeate transdermally were those possessing a very narrow and specific combination of physicochemical properties. However, rapid advances in bioengineering have led to the emergence of various new "active" enhancement technologies designed to transiently circumvent the barrier function of the stratum corneum. These novel systems, using iontophoresis, sonophoresis, electroporation, or microneedle arrays, will greatly expand the range of drugs that can be delivered transdermally. Crucially, the delivery of macromolecules will become possible and the transdermal flux of other molecules could be enhanced by several orders of magnitude. This article sequentially reviews the basis of each of the new enhancement techniques and discusses how these emerging technologies will influence transdermal therapy in the coming years.
More Related Videos
Related Concept Videos
Transdermal Drug Delivery Systems
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Oral Drug Delivery Systems: Introduction
Modified-Release Drug Delivery Systems: Stimuli-Activated


