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Updated: Jul 29, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

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Ketoconazole binds to the human androgen receptor

C Eil1

  • 1Department of Internal Medicine, Naval Hospital, Bethesda, Maryland.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|August 1, 1992
PubMed
Summary

Ketoconazole, an antifungal drug, binds to human androgen receptors (AR) in vitro, potentially explaining its side effects like decreased libido. This interaction was competitive but unlikely to occur at typical in vivo doses.

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