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Related Experiment Videos

Interventions for treating depression after stroke.

M L Hackett1, C S Anderson, A O House

  • 1Clinical Trials Research Unit, University of Auckland, Private Bag 92019, Auckland, New Zealand.

The Cochrane Database of Systematic Reviews
|July 22, 2004
PubMed
Summary
This summary is machine-generated.

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Treatments for depression after stroke, including pharmacotherapy and psychotherapy, showed no strong evidence of benefit for complete remission. Further research is needed to determine effective management strategies for post-stroke depression.

Area of Science:

  • Neurology
  • Psychiatry
  • Evidence-based Medicine

Background:

  • Post-stroke depression and anxiety disorders are frequently underdiagnosed and undertreated.
  • Difficulties in diagnosing mood disorders in stroke survivors with disabilities may contribute to inadequate treatment.
  • Uncertainty exists regarding the efficacy of available therapies for depression in stroke patients.

Purpose of the Study:

  • To evaluate the effectiveness of pharmacological, psychological, or electroconvulsive therapy (ECT) for treating depression in patients following a stroke.
  • To determine if these treatments improve outcomes in stroke survivors with depression.

Main Methods:

  • A systematic review of randomized and quasi-randomized controlled trials was conducted.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, CINAHL, and PsychINFO up to September 2002.

Related Experiment Videos

  • Included trials comparing pharmacotherapy or psychotherapy for depression in acute stroke patients against placebo or standard care.

    • Main Results:

    • Nine trials with 780 participants were included; seven on pharmacotherapy and two on psychotherapy. No ECT trials were found.
    • Analyses were limited by inconsistent diagnostic and outcome criteria.
    • No strong evidence supported pharmacotherapy or psychotherapy for complete depression remission; however, some depression rating scales showed improvement, with an increase in anxiety noted.

    Conclusions:

    • Current evidence does not support the routine use of pharmacotherapy or psychotherapy for post-stroke depression.
    • More research is necessary to establish optimal management guidelines for depression after stroke.