Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Omega-3 fatty acids for intermittent claudication.

T Sommerfield¹, W R Hiatt

¹Lothian NHS Board, 148 Pleasance, Edinburgh, UK, EH8 9RS.

The Cochrane Database of Systematic Reviews

|July 22, 2004

Summary

Omega-3 fatty acids show potential benefits for intermittent claudication by improving triglyceride levels and blood pressure. However, current evidence does not support improved walking distance or clinical outcomes, necessitating further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings.

Journal of thrombosis and haemostasis : JTH·2015

Same author

Toxicity of a novel therapeutic agent targeting mitochondrial complex I.

Clinical pharmacology and therapeutics·2015

Same author

Response to ‘Statement from the European Society of Vascular Surgery and the World Federation of Vascular Surgery Societies’ Inter-Society Consensus Document (TASC) III and International Standards for Vascular Care (ISVaC).

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2014

Same author

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events.

European journal of preventive cardiology·2013

Same author

Balancing risk and benefit in venous thromboembolism trials: concept for a bivariate endpoint trial design and analytic approach.

Journal of thrombosis and haemostasis : JTH·2013

Same author

Comparative effectiveness and safety of the novel oral anticoagulants: do the pivotal clinical trials point to a new paradigm?

Journal of thrombosis and haemostasis : JTH·2012

Area of Science:

Cardiovascular Health
Nutritional Science
Peripheral Vascular Diseases

Background:

Omega-3 fatty acids are recognized for their efficacy in managing coronary artery disease.
Similarities in pathogenesis suggest potential benefits for peripheral arterial disease, including intermittent claudication.

Purpose of the Study:

To evaluate the impact of omega-3 fatty acid supplementation on individuals experiencing intermittent claudication.

Main Methods:

Systematic review of randomized controlled trials comparing omega-3 fatty acids with placebo.
Searches included major databases (Cochrane), pharmaceutical literature, and nutritional organizations.
Data extraction and quality assessment performed by two independent reviewers.

Related Experiment Videos

Main Results:

Four studies with 203 participants were analyzed; overall study quality was good.
Omega-3 supplementation reduced triglyceride levels and diastolic blood pressure but increased total and LDL cholesterol.
No significant improvements were observed in pain-free walking distance, maximal walking distance, or ankle brachial pressure index.

Conclusions:

Omega-3 fatty acids demonstrate favorable biochemical and hemodynamic effects in intermittent claudication patients.
Current evidence does not confirm improved clinical outcomes or walking distances.
Further research is required to ascertain short- and long-term effects on clinically relevant outcomes.