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Updated: Aug 9, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Immunological evaluation of cefodizime: a unique molecule among cephalosporins
1INSERM U 294, Laboratoire d'Immunologie et d'Hématologie, CHU Xavier Bichat, Paris, France.
Abstract:
The immunomodulatory properties of cefodizime, a new aminothiazolyl cephalosporin, are reviewed. Cefodizime displays in vitro and ex vivo stimulatory effects on phagocyte bactericidal function. It also increases certain lymphocyte responses, including delayed type hypersensitivity and antibody production. In addition, it restores various immune functions in immunocompromised animals and humans. The immunomodulating activity of this drug is further supported by its in vivo efficacy in experimental models of infections using cefodizime-sensitive or -resistant pathogens. Cefodizime appears to be a promising molecule, exhibiting potent antimicrobial activity and exerting potentially beneficial effects on the immune system.
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