Related Experiment Videos
Mitochondria-lytic action of warfarin in lymphocytes
B Berkarda1, O Arda, M Tasyurekli
1Department of Medical Oncology, Cerrahpaşa School of Medicine, Istanbul, Turkey.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|August 1, 1992
Abstract:
Warfarin given as a single dose of 20 mg induces lysis of mitochondria in lymphocytes from chronic and acute lymphocytic leukemias studied under the electron microscope. Normal lymphocytes remain unchanged. This cytotoxic actin may be due to superoxide radicals produced in the malignant cells by warfarin, which is a potent electron-transferring substance.