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Metrondazole-induced neurotoxicity

A K Gupta1, M P Agarwal, R Avasthi

  • 1Department of Medicine, University College of Medical Sciences and GTB Hospital, Delhi 110 095.

The Journal of the Association of Physicians of India
|July 23, 2004
PubMed

Insights

Prolonged metronidazole use, especially high doses for liver abscess, can cause serious neurotoxicity. Monitor patients for symptoms like ataxia, disorientation, and neuropathy during treatment.

Area of Science:

  • Neurology
  • Pharmacology
  • Infectious Diseases

Background:

  • Metronidazole is a commonly prescribed antibiotic for anaerobic infections, including liver abscesses.
  • Prolonged use and high dosages are sometimes necessary for complex or refractory cases.

Observation:

  • A 50-year-old male patient presented with acute neurological symptoms after extended metronidazole therapy for a liver abscess.
  • Symptoms included ataxia, disorientation, distal symmetrical sensory loss, and proximal motor neuropathy.

Findings:

  • The patient's clinical presentation was consistent with metronidazole-induced neurotoxicity.
  • This adverse effect appears linked to the duration and dosage of metronidazole administration.

Implications:

  • Clinicians should be vigilant for neurological side effects in patients on long-term or high-dose metronidazole.
  • Regular monitoring for neurotoxicity is crucial to ensure patient safety during metronidazole treatment.

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