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[Studies on sex hormone-binding globulin in the prostate]
1Department of Urology, Shenzhen Peoples Hospital, Jinan University Medical College, Shenzhen, Guang-dong 518020, China. djht@sohu.com
Objective:
To assay the existence of SHBG in prostatic tissue and analyze the effects of SHBG on the prostate and prostatic hyperplasia.
Methods:
Prostate tissue cytosolic and nuclear fractions were obtained from 32 cases of benign prostatic hyperplasia (BPH), 11 cases of elderly control, and 22 cases of the normal young and middle-aged. SHBG in cytosol and nucleus was evaluated by two-site immunoradiometric assay based on the 125I-labelled monoclonal antibody.
Results:
The study testified the existence of SHBG in the cytosol of prostatic tissue. SHBG in BPH tissue [(5.11 +/- 1.37) fmol/g wet tissue] was a little more than that in the young and middle-aged group [(4.98 +/- 1.39) fmol/g wet tissue] and the elderly group [(5.06 +/- 1.27) fmol/g wet tissue], but there was no significance among the three groups (P > 0.05).
Conclusion:
SHBG in the prostate can bind and accumlate androgen, which is related to prostatic physiology and contributes to the etiology of BPH.