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Related Experiment Videos

Internal stochastic resonance under two-parameter modulation in intercellular calcium ion oscillations.

Ya Ping Li1, Qian Shu Li

  • 1School of Science, Beijing Institute of Technology, Beijing 100081, China.

The Journal of Chemical Physics
|July 23, 2004
PubMed
Summary

Internal stochastic resonance (ISR) in calcium signaling shows noise can enhance oscillations. Adding noise to two parameters simultaneously (ISBR) can lead to complex behaviors, influenced by proximity to bifurcation points.

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Area of Science:

  • Cellular Biology
  • Biophysics
  • Theoretical Biology

Background:

  • Intercellular calcium ion oscillations are crucial for cell communication.
  • Stochastic resonance (SR) is a phenomenon where noise enhances signal detection in nonlinear systems.
  • Internal stochastic resonance (ISR) explores SR within biological systems without external periodic forcing.

Purpose of the Study:

  • Investigate internal stochastic resonance (ISR) in a model of intercellular calcium ion oscillations.
  • Analyze the effects of modulating extracellular stimulation (beta) and leak rate (k(f)) on ISR.
  • Explore internal stochastic biresonance (ISBR) when noise is applied to both parameters simultaneously.

Main Methods:

  • Computational modeling of intercellular calcium ion oscillations.

Related Experiment Videos

  • Analysis of system dynamics under varying noise levels for individual parameters (beta, k(f)).
  • Simultaneous noise application to both beta and k(f) to study ISBR.

    • Main Results:

    • ISR was observed when noise was applied to either the degree of extracellular stimulation (beta) or the leak rate (k(f)).
    • Internal stochastic biresonance (ISBR) occurred when noise was simultaneously applied to both beta and k(f).
    • The distance to the bifurcation point significantly influenced ISBR, either enhancing or suppressing it, and affected the number of ISR peaks.

    Conclusions:

    • Noise modulation of key parameters can induce and control internal stochastic resonance in calcium signaling models.
    • Simultaneous noise application (ISBR) presents complex dynamics sensitive to system proximity to bifurcation points.
    • This study highlights the potential role of intrinsic noise in regulating intercellular communication dynamics.