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Urinary bladder contraction and relaxation: physiology and pathophysiology
Karl-Erik Andersson1, Anders Arner
1Dept. of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Physiological Reviews
|July 23, 2004
Summary
This review details detrusor smooth muscle properties, focusing on its contractile system, signaling, and receptors. It also covers functional changes in conditions like lower urinary tract symptoms (LUTS).
Area of Science:
- Urology
- Physiology
- Cell Biology
Background:
- The detrusor smooth muscle forms the urinary bladder wall, crucial for bladder function during filling and voiding.
- Its contractile and relaxation abilities are vital for normal micturition.
- Detrusor function is influenced by nervous and hormonal systems, involving multiple receptors and signaling pathways.
Purpose of the Study:
- To review and synthesize current knowledge on detrusor smooth muscle properties.
- To explore recent advances in understanding its contractile system, cellular signaling, membrane properties, and receptors.
- To describe alterations in these systems during pathological bladder conditions.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of cellular signaling pathways and receptor functions.
- Examination of detrusor smooth muscle properties in physiological and pathological states.
Main Results:
- Detrusor smooth muscle exhibits complex contractile properties regulated by diverse cellular mechanisms.
- Multiple receptors and signaling pathways modulate detrusor activity.
- Pathological conditions, such as lower urinary tract symptoms (LUTS) and bladder outlet obstruction, involve significant detrusor alterations.
Conclusions:
- A comprehensive understanding of detrusor smooth muscle is essential for addressing bladder dysfunction.
- Further research into detrusor alterations in disease states is warranted.
- Investigating novel therapeutic targets within detrusor signaling pathways may improve treatment outcomes.