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Anchor residues in protein-protein interactions

Deepa Rajamani1, Spencer Thiel, Sandor Vajda

  • 1Departments of Biology and Biomedical Engineering and Bioinformatics Program, Boston University, Boston, MA 02215, USA.

Proceedings of the National Academy of Sciences of the United States of America
|July 23, 2004
PubMed
Summary

Protein recognition involves smaller proteins anchoring side chains in binding grooves, forming stable intermediates. This mechanism simplifies protein-protein interactions and guides evolutionary conservation.

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