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Alveolar soft-part sarcoma presenting with multiple intracranial metastases
G Samson Sujit Kumar1, Geeta Chacko, Ari G Chacko
1Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, India.
Neurology India
|July 23, 2004
Summary
A rare metastatic alveolar soft part sarcoma caused brain lesions and seizures in a 28-year-old man. Whole brain radiotherapy was recommended for treatment.
Area of Science:
- Neuro-oncology
- Pathology
- Radiology
Background:
- Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma.
- Intracranial metastasis from ASPS is exceptionally uncommon.
- Clinical presentation can be nonspecific, mimicking primary brain tumors.
Observation:
- A 28-year-old male presented with symptoms of increased intracranial pressure and a seizure.
- Computed Tomography (CT) demonstrated multiple contrast-enhancing lesions within the brain.
- Biopsy confirmed metastatic alveolar soft part sarcoma as the etiology of the intracranial lesions.
Findings:
- Histopathological diagnosis of metastatic alveolar soft part sarcoma.
- Radiological evidence of multiple intracranial metastases.
- Association of ASPS metastasis with raised intracranial pressure and seizures.
Implications:
- Highlights the importance of considering rare metastatic disease in the differential diagnosis of intracranial lesions.
- Underscores the need for thorough histopathological evaluation for accurate diagnosis.
- Suggests whole brain radiotherapy as a potential treatment modality for intracranial ASPS metastasis.