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Fenofibrate-induced myopathy.

Bhaskar Ghosh1, S Sengupta, B Bhattacharjee

  • 1Department of Neurology and Medicine, B. R. Singh Hospital and Centre for Medical Education and Research, Central Hospital of Eastern Railway, Sealdah, Kolkata - 700 014, India. drbghosh@vsnl.net

Neurology India
|July 23, 2004
PubMed
Summary
This summary is machine-generated.

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Fenofibrate can cause rare muscle damage (myopathy), leading to pain and weakness. This case report highlights a patient who recovered after discontinuing fenofibrate, likely the first such report from India.

Area of Science:

  • Pharmacology
  • Neurology
  • Toxicology

Background:

  • Fenofibrate is a common lipid-lowering drug.
  • Drug-induced myopathy is a known but rare adverse effect.
  • Understanding rare adverse events is crucial for patient safety.

Observation:

  • A patient developed severe muscle pain and quadriparesis.
  • Symptoms appeared after 35 days of fenofibrate 200mg daily.
  • The patient's condition improved significantly upon drug cessation.

Findings:

  • This case suggests a potential link between fenofibrate and severe myopathy.
  • The adverse event resolved after withdrawal of the offending drug.
  • This may be the first documented case of fenofibrate-induced myopathy in India.

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Implications:

  • Clinicians should be vigilant for myopathy in patients on fenofibrate.
  • Early recognition and drug discontinuation can lead to recovery.
  • Further research may be needed to understand the incidence and risk factors.