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Emergence of ciprofloxacin-resistant pseudomonas in chronic suppurative otitis media

C H Jang1, S Y Park

  • 1Wonkwang Medical School, Iksan, South Korea. chul@wonkwang.ac.kr

Clinical Otolaryngology and Allied Sciences
|July 24, 2004
PubMed

Insights

Chronic suppurative otitis media (CSOM) treatment with ciprofloxacin failed in all patients due to resistant Pseudomonas aeruginosa. Imipenem showed the highest effectiveness against these resistant bacteria.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Microbiology

Background:

  • Chronic suppurative otitis media (CSOM) frequently involves Pseudomonas aeruginosa.
  • Topical ciprofloxacin is a common treatment for P. aeruginosa infections.
  • Recurrent otorrhoea in CSOM can indicate treatment failure.

Purpose of the Study:

  • To evaluate patients with recurrent otorrhoea due to CSOM unresponsive to topical ciprofloxacin.
  • To identify the causative organisms and their antibiotic susceptibility patterns.

Main Methods:

  • Retrospective review of 88 patients with CSOM and otorrhoea.
  • Bacteriological specimens processed and identified via standard cultures.
  • In vitro antimicrobial susceptibility testing using agar disc diffusion against 16 antibiotics.

Main Results:

  • Pseudomonas aeruginosa resistant to ciprofloxacin was isolated in all cases.
  • Imipenem demonstrated the highest susceptibility rate (96.5%).
  • Other effective agents included amikacin (55.6%), piperacillin/tazobactam (37.5%), and ceftazidime (31.8%).

Conclusions:

  • Ciprofloxacin resistance in P. aeruginosa causing CSOM is increasing.
  • Continuous surveillance of antimicrobial resistance is crucial.
  • Alternative antibiotic therapies are needed for ciprofloxacin-resistant infections.

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