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Updated: Aug 23, 2026
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
Thrombophilia and stillbirth: possible connection by intrauterine growth restriction
Zeev Weiner1, Ronit Beck-Fruchter, Amir Weiss
1Department of Obstetric and Gynecology, Ha'Emek Medical Center, Afula, Israel.
Objective:
To define the association between thrombophilia and unexplained stillbirth.
Design:
A case-control study.
Setting:
Obstetric department in a university affiliated hospital (Ha'Emek Medical Center, Afula).
Population:
A total of 53 women who delivered stillborns between March 1998 and June 2002 and 59 women with unremarkable obstetric history who delivered at the same period.
Methods:
Presence of genetic and acquired markers of thrombophilia was investigated.
Main Outcome Measure:
Presence or absence of thrombophilia.
Results:
Thrombophilia was found in 34% of the women who delivered stillborns and in 20% of the 59 women with normal pregnancies (non-significant). However, significantly higher prevalence of thrombophilia (73%) was found in women who delivered small for gestational age stillborns compared with women who delivered normal birthweight stillborns (73%vs 18.4%, P < 0.0001).
Conclusions:
There is no association between thrombophilia and stillbirth, overall. However, there is a clear association between thrombophilia and stillbirth of extremely growth restricted infants.
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