Evidence for the role of oviduct secretions in sperm function, fertilization and embryo development

The oviduct is a dynamic organ which facilitates gamete function, fertilization and embryo development. Secretions of the oviduct, recovered by tissue culture or cannulation techniques have been used to define the composition of the oviduct milieu, as well as functions associated with stage of the reproductive cycle or region of the oviduct. Several oviduct proteins have been shown to associate with the gametes and embryos. Ongoing studies are directed at identifying oviduct proteins and determining their function. Oviduct-specific glycoproteins (OSG) have been purified from the oviduct and shown in vitro to have positive affects on sperm capacitation, sperm-ovum binding, ovum penetration and embryo development. Osteopontin, another oviduct secretion, also has been shown to stimulate fertilization and embryo development. The picture emerging is that some components of the oviduct milieu have overlapping functions to collectively provide a failsafe system to ensure fertility in vivo so that success is not dependent on a single component.