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Related Experiment Videos

Fecundity genes in sheep.

G H Davis1

  • 1AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand. george.davis@agresearch.co.nz

Animal Reproduction Science
|July 24, 2004
PubMed
Summary
This summary is machine-generated.

Researchers are identifying major genes that increase ovulation rates in sheep, aiding genetic improvement programs. DNA tests for these prolificacy genes, like BMPR-1B and BMP15, enable marker-assisted selection for enhanced sheep breeding.

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Area of Science:

  • Animal Genetics
  • Reproductive Biology
  • Sheep Breeding

Background:

  • Increasing interest since 1980 in identifying and utilizing major genes for prolificacy in sheep.
  • Mutations in BMPR-1B, BMP15, and GDF9 genes are known to increase ovulation rates.
  • Other prolificacy genes exist, indicated by inheritance patterns, but their mutations are not yet located.

Purpose of the Study:

  • To review identified major genes influencing prolificacy in sheep.
  • To describe the inheritance patterns and effects of these prolificacy genes.
  • To highlight the role of DNA testing in sheep genetic improvement.

Main Methods:

  • Literature review of identified prolificacy genes in sheep.
  • Analysis of inheritance patterns (autosomal dominant, over-dominant, X-linked).

Related Experiment Videos

  • Examination of mutation effects on ovulation rate and associated phenotypes.

    • Main Results:

    • Mutations in BMPR-1B, BMP15, and GDF9 increase ovulation rates.
    • BMP15 has four identified mutations, all yielding the same phenotype.
    • Inheritance modes vary: autosomal dominant (BMPR-1B), autosomal over-dominant (GDF9), X-linked over-dominant (BMP15), X-linked maternally imprinted (FecX2).
    • Mutation effects range from 0.4 (FecX2) to 1.5 (BMPR-1B) extra ovulations per oestrus.

    Conclusions:

    • Several major genes significantly impact sheep prolificacy.
    • Understanding gene inheritance and effects is crucial for breeding programs.
    • DNA tests facilitate marker-assisted selection for genetic improvement of prolificacy in sheep.